TY - JOUR
AU - 
AB - MINI REVIEW published: 29 September 2017 doi: 10.3389/fmolb.2017.00067 Handshakes and Fights: The Regulatory Interplay of RNA-Binding Proteins Erik Dassi* Centre for Integrative Biology, University of Trento, Trento, Italy What drives the flow of signals controlling the outcome of post-transcriptional regulation of gene expression? This regulatory layer, presiding to processes ranging from splicing to mRNA stability and localization, is a key determinant of protein levels and thus cell phenotypes. RNA-binding proteins (RBPs) form a remarkable army of post-transcriptional regulators, strong of more than 1,500 genes implementing this expression fine-tuning plan and implicated in both cell physiology and pathology. RBPs can bind and control a wide array of RNA targets. This sheer amount of interactions form complex regulatory networks (PTRNs) where the action of individual RBPs cannot be easily untangled from each other. While past studies have mostly focused on the action of individual RBPs on their targets, we are now observing an increasing amount of evidence describing Edited by: Ulf Andersson Ørom, the occurrence of interactions between RBPs, defining how common target RNAs are Max Planck Institute for Molecular regulated. This suggests that the flow of signals in PTRNs is driven by the intertwined Genetics, Germany contribution of multiple RBPs, 
TI - Handshakes and Fights: The Regulatory Interplay of RNA-Binding Proteins
JF - Frontiers in Molecular Biosciences
DO - 10.3389/fmolb.2017.00067
DA - 2017-09-29
UR - https://www.deepdyve.com/lp/unpaywall/handshakes-and-fights-the-regulatory-interplay-of-rna-binding-proteins-T0HIdUV0VF
DP - DeepDyve
ER -