TY - JOUR
AU - Newman, Anne B.
AB - Abstract Although loss of muscle mass is considered a cause of diminished muscle strength with aging, little is known regarding whether composition of aging muscle affects strength. The skeletal muscle attenuation coefficient, as determined by computed tomography, is a noninvasive measure of muscle density, and lower values reflect increased muscle lipid content. This investigation examined the hypothesis that lower values for muscle attenuation are associated with lower voluntary isokinetic knee extensor strength at 60°/s in 2,627 men and women aged 70–79 yr participating in baseline studies of the Health ABC Study, a longitudinal study of health, aging, and body composition. Strength was higher in men than in women (132.3 ± 34.5 vs. 81.4 ± 22.0 N · m, P < 0.01). Men had greater muscle attenuation values (37.3 ± 6.5 vs. 34.7 ± 7.0 Hounsfield units) and muscle cross-sectional area (CSA) at the midthigh than women (132.7 ± 22.4 vs. 93.3 ± 17.5 cm 2 , P < 0.01 for both). The strength per muscle CSA (specific force) was also higher in men (1.00 ± 0.21 vs. 0.88 ± 0.21 N · m · cm −2 ). The attenuation coefficient was significantly lower for hamstrings than for quadriceps (28.7 ± 8.7 vs. 41.1 ± 6.9 Hounsfield units, P < 0.01). Midthigh muscle attenuation values were lowest ( P < 0.01) in the eldest men and women and were negatively associated with total body fat ( r = −0.53, P < 0.01). Higher muscle attenuation values were also associated with greater specific force production ( r = 0.26, P < 0.01). Multivariate regression analysis revealed that the attenuation coefficient of muscle was independently associated with muscle strength after adjustment for muscle CSA and midthigh adipose tissue in men and women. These results demonstrate that the attenuation values of muscle on computed tomography in older persons can account for differences in muscle strength not attributed to muscle quantity. aging computed tomography adipose tissue muscle strength Footnotes This project was supported by National Institute on Aging Grants N01-AG-6-2106, N01-AG-6-2102, and N01-AG-6-2103. B. H. Goodpaster was supported by National Institute on Aging Career Development Award K01-AG-00851. Address for reprint requests and other correspondence: B. H. Goodpaster, E 1140 Biomedical Science Tower, University of Pittsburgh, Pittsburgh, PA 15261 (E-mail: bgood+@pitt.edu ). The costs of publication of this article were defrayed in part by the payment of page charges. The article must therefore be hereby marked “ advertisement ” in accordance with 18 U.S.C. Section 1734 solely to indicate this fact. Copyright © 2001 the American Physiological Society
TI - Attenuation of skeletal muscle and strength in the elderly: The Health ABC Study
JF - Journal of Applied Physiology
DA - 2001-06-01
UR - https://www.deepdyve.com/lp/the-american-physiological-society/attenuation-of-skeletal-muscle-and-strength-in-the-elderly-the-health-TRs5P6Mxe0
VL - 90
IS - 6
DP - DeepDyve
ER -