TY - JOUR
AU - van den Born, Bert-Jan H.
AB - Effects on Peripheral and Central Blood Pressure of Cocoa With Natural or High-Dose Theobromine A Randomized, Double-Blind Crossover Trial Bas van den Bogaard, Richard Draijer, Berend E. Westerhof, Anton H. van den Meiracker, Gert A. van Montfrans, Bert-Jan H. van den Born Abstract—Flavanol-rich cocoa products have been reported to lower blood pressure. It has been suggested that theobromine is partially responsible for this effect. We tested whether consumption of flavanol-rich cocoa drinks with natural or added theobromine could lower peripheral and central blood pressure. In a double-blind, placebo-controlled 3-period crossover trial we assigned 42 healthy individuals (age 62
4.5 years; 32 men) with office blood pressure of 130 to 159 mm Hg/85 to 99 mm Hg and low added cardiovascular risk to a random treatment sequence of dairy drinks containing placebo, flavanol-rich cocoa with natural dose consisting of 106 mg of theobromine, or theobromine- enriched flavanol-rich cocoa with 979 mg of theobromine. Treatment duration was 3 weeks with a 2-week washout. The primary outcome was the difference in 24-hour ambulatory systolic blood pressure between placebo and active treatment after 3 weeks. The difference in central systolic blood pressure between placebo and active treatment was a secondary outcome. Treatment with theobromine-enriched 
TI - Effects on Peripheral and Central Blood Pressure of Cocoa With Natural or High-Dose Theobromine A Randomized, Double-Blind Crossover Trial
JF - Hypertension
DO - 10.1161/HYPERTENSIONAHA.110.158139
DA - 2010-11-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/effects-on-peripheral-and-central-blood-pressure-of-cocoa-with-natural-TTSB0MPHiA
SP - 839
EP - 846
VL - 56
IS - 5
DP - DeepDyve
ER -