TY - JOUR
AU - Karlsson, L
AB - HLA-DM (DM) facilitates peptide loading of major histocompatibility complex class II molecules in human cell lines. Mice lacking functional H2-M, the mouse equivalent of DM, have normal amounts of class II molecules at the cell surface, but most of these are associated with invariant chain-derived CLIP peptides. These mice contain large numbers of CD4+ T cells, which is indicative of positive selection in the thymus. Their CD4+ cells were unresponsive to self H2-M-deficient antigen-presenting cells (APCs) but were hyperreactive to wild-type APCs. H2-M-deficient APCs failed to elicit proliferative responses from wild-type T cells.
TI - Antigen presentation and T cell development in H2-M-deficient mice.
JF - Science (New York, N.Y.)
DO - 10.1126/science.271.5253.1278
DA - 1996-07-10
UR - https://www.deepdyve.com/lp/pubmed/antigen-presentation-and-t-cell-development-in-h2-m-deficient-mice-TygP0GlUT0
SP - 1278
EP - 81
VL - 271
IS - 5253
DP - DeepDyve
ER -