TY - JOUR
AU - Mary Carrington, Michael Dean, Maureen P. Martin, Stephen J. O'Brien
AB - The chemokine receptor gene, CCR5 , has become a central theme in studies of host genetic effects on HIV-1 pathogenesis ever since the discovery that the CCR5 molecule serves as a major cell surface co-receptor for the virus. A growing number of genetic variants within the coding and 5′ regulatory region of CCR5 have been identified, several of which have functional consequences for HIV-1 pathogenesis. Here we review the CCR5 literature describing CCR5 polymorphism and the functional ramifications that several of these variants have on HIV-1 infection and progression to AIDS. The multiplicity of CCR5 genetic effects on HIV-1 disease underscores the critical importance of this gene in controlling AIDS pathogenesis and provides the logic for development of therapeutic strategies that target the interaction of HIV-1 envelope and CCR5 in HIV-1 associated disease. © 1999 Oxford University Press « Previous | Next Article » Table of Contents This Article Hum. Mol. Genet. (1999) 8 (10): 1939-1945. doi: 10.1093/hmg/8.10.1939 » Abstract Free Full Text (HTML) Free Full Text (PDF) Free Classifications Article Services Article metrics Alert me when cited Alert me if corrected Find similar articles Similar articles in Web of Science Similar articles in PubMed Add to my archive Download citation Request Permissions Citing Articles Load citing article information Citing articles via CrossRef Citing articles via Scopus Citing articles via Web of Science Citing articles via Google Scholar Google Scholar Articles by Carrington, M. Articles by O'Brien, S. J. Search for related content PubMed PubMed citation Articles by Carrington, M. Articles by Dean, M. Articles by Martin, M. P. Articles by O'Brien, S. J. Related Content Load related web page information Share Email this article CiteULike Delicious Facebook Google+ Mendeley Twitter What's this? 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TI - Genetics of HIV-1 Infection: Chemokine Receptor Ccr5 Polymorphism and Its Consequences
JF - Human Molecular Genetics
DO - 10.1093/hmg/8.10.1939
DA - 1999-01-01
UR - https://www.deepdyve.com/lp/oxford-university-press/genetics-of-hiv-1-infection-chemokine-receptor-ccr5-polymorphism-and-VB1CWftsBC
SP - 1939
VL - 8
IS - 10
DP - DeepDyve
ER -