TY - JOUR
AU1 - Lu, Wen
AU2 - Kang, Jing
AU3 - Hu, Ke
AU4 - Tang, Si
AU5 - Zhou, Xiufang
AU6 - Xu, Lifang
AU7 - Li, Yuanyuan
AU8 - Yu, Shuhui
AB - Sleep Breath (2017) 21:667–677 DOI 10.1007/s11325-016-1449-2 SLEEP BREATHING PHYSIOLOGY AND DISORDERS � ORIGINAL ARTICLE The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia 1 1 1 1 1 1 Wen Lu & Jing Kang & Ke Hu & Si Tang & Xiufang Zhou & Lifang Xu & 1 1 Yuanyuan Li & Shuhui Yu Received: 26 January 2016 /Revised: 23 November 2016 /Accepted: 22 December 2016 /Published online: 11 January 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract RhoA/ROCK in CIH remains unclear and requires further Background Obstructive sleep apnea syndrome, which is a study. risk factor for resistant hypertension, is characterized by Objective This study aimed to investigate the role of the chronic intermittent hypoxia (CIH) and is associated with NADPH oxidase 4 (Nox4)-induced ROS/RhoA/ROCK path- many cardiovascular diseases. CIH elicits systemic oxidative way in CIH-induced hypertension in rats. stress and sympathetic hyperactivity, which lead to hyperten- Methods Male Sprague–Dawley rats were exposed to CIH for 21 days (intermittent hypoxia of 21% O for 60 s and 5% O sion. Rho kinases (ROCKs) are considered to be major effec- 2 2 tors of the small GTPase RhoA and have been extensively for 
TI - The role of the Nox4-derived ROS-mediated RhoA/Rho kinase pathway in rat hypertension induced by chronic intermittent hypoxia
JF - Sleep and Breathing
DO - 10.1007/s11325-016-1449-2
DA - 2017-01-11
UR - https://www.deepdyve.com/lp/springer-journals/the-role-of-the-nox4-derived-ros-mediated-rhoa-rho-kinase-pathway-in-VhwiI0rc4k
SP - 667
EP - 677
VL - 21
IS - 3
DP - DeepDyve
ER -