TY - JOUR
AU - Natkunam, Yasodha
AB - ORIGINAL ARTICLE Expression Profiles of MYC Protein and MYC Gene Rearrangement in Lymphomas Karen M. Chisholm, MD, PhD,* Charles D. Bangs, BS,* Carlos E. Bacchi, MD,w Hernan Molina-Kirsch, MD,z Athena Cherry, PhD,* and Yasodha Natkunam, MD, PhD* he MYC oncogene encodes a transcription factor that Abstract: MYC translocations are a defining feature of Burkitt Tpromotes cell growth and proliferation as well as lymphoma and a group of diffuse large B-cell lymphoma differentiation and apoptosis. Approximately 15% of (DLBCL) with inferior outcome. However, the clinical relevance human genes are thought to be regulated by the MYC of MYC gene rearrangement and its relationship with MYC protein, which include genes involved in cell cycle control, protein expression has not been well characterized in lympho- metabolism, protein biosynthesis, chromatin remodeling, 1,2 mas. Tissue microarrays containing 1214 lymphomas were suc- and stem cell self-renewal. Perturbation of MYC reg- cessfully evaluated by immunohistochemistry using anti-MYC ulation, through constitutive or deregulated expression of clone Y69 and a dual-color break-apart fluorescence in situ the MYC protein, in the appropriate context, leads to 3–6 hybridization probe to detect MYC gene rearrangements. Ag- oncogenesis. gressive B-cell lymphomas including Burkitt lymphoma and The role of MYC in oncogenesis was 
TI - Expression Profiles of MYC Protein and  MYC
JF - American Journal of Surgical Pathology
DO - 10.1097/PAS.0000000000000365
DA - 2015-03-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/expression-profiles-of-myc-protein-and-myc-We6P6DRKR0
SP - 294–303-294&ndash
EP - ndash;303-294–303
VL - 39
IS - 3
DP - DeepDyve
ER -