TY - JOUR
AU1 - Joshi, Navin
AU2 - Mishra, Neeraj
AU3 - Rai, Vineet Kumar
AB - PurposeLess local availability and higher skin permeation restrict wide application of silver sulfadiazine (SSD) formulations against infectious burn wound.AimWe aimed to develop β-cyclodextrin inclusion complex-based in situ pluronic gel of SSD (β-CD-ssd P-Gel).MethodsFormation of inclusion complex was confirmed by FT-IR, DSC, SEM, and XRD and checked for improved solubility.Results and DiscussionPoloxamer (407/118)-based in situ gel of inclusion complex was prepared and characterized for its gelation temperature (33.50 °C), viscosity (1159.25 ± 5.60 cps), pH (6.4 ± 0.56), and drug content (91.56 ± 1.62%). The developed gel showed slow drug release and slow permeation of the drug through the skin. It showed broader zone of Staphylococcus aureus growth inhibition (31 ± 0.20 mm) and high wound contraction (98.89%) when compared with the marketed formulation (26 ± 0.20 mm and 58.00%, respectively).ConclusionsA consistent, biocompatible, β-CD-ssd P-Gel was prepared successfully. It was found able to ensure increased local availability by forming viscous gel below body temperature, high SSD availability at the desired site, and high efficacy against infectious wound.
TI - Development and Evaluation of In Situ Gel of Silver Sulfadiazine for Improved Therapeutic Efficacy Against Infectious Burn Wound
JF - Journal of Pharmaceutical Innovation
DO - 10.1007/s12247-020-09464-y
DA - 2021-09-01
UR - https://www.deepdyve.com/lp/springer-journals/development-and-evaluation-of-in-situ-gel-of-silver-sulfadiazine-for-WoG0ZAvLC8
SP - 537
EP - 550
VL - 16
IS - 3
DP - DeepDyve
ER -