TY - JOUR
AU1 - Kato, Takaharu
AU2 - Alonso, Sergio
AU3 - Muto, Yuta
AU4 - Noda, Hiroshi
AU5 - Miyakura, Yasuyuki
AU6 - Suzuki, Koichi
AU7 - Tsujinaka, Shingo
AU8 - Saito, Masaaki
AU9 - Perucho, Manuel
AU1 - Rikiyama, Toshiki
AB - Abstract Background Incidence and clinical characteristics of synchronous colorectal cancer (sCRC) patients significantly vary among studies, likely due to differences in surveillance methodology. If remain undetected, sCRC can progress to more advanced stages seriously aggravating patient prognosis. We studied the incidence and clinicopathological characteristics of Japanese patients with sCRCs who underwent surgery for primary CRC and received exhaustive perioperative surveillance. Methods We recruited 1005 patients with surgically resected CRCs between January 2007 and December 2011. The associations of clinical and pathological factors with sCRC development were assessed by univariate and multivariate logistic regression. Results Eighty-four patients (8.4 %) developed sCRCs, 16 of them (19.0 %) harboring three or more cancers. Companion sCRCs were smaller and earlier stage than the index lesion (P < 0.0001). In multivariate analysis, advanced age (odds ratio (OR) 1.03 per year; P = 0.009) and left colon tumor location (OR 1.78; P = 0.013) are associated with higher risk of sCRCs, particularly in females. Overall survival did not differ between solitary CRC and sCRC (P = 0.62). Conclusions Our results highlight the importance of perioperative colonoscopy examination to ensure the absence of sCRCs that, being small and early staged, are more difficult to detect. The incidence of sCRC, and notably of triple or more sCRCs, was higher than previously recognized. Because they are also significantly higher than expected by merely stochastic accumulation of individual cancerous lesions, we suggest that the occurrence of many sCRC reflects a hitherto uncharacterized predisposition condition.
TI - Clinical characteristics of synchronous colorectal cancers in Japan
JF - World Journal of Surgical Oncology
DO - 10.1186/s12957-016-1027-x
DA - 2016-12-01
UR - https://www.deepdyve.com/lp/springer-journals/clinical-characteristics-of-synchronous-colorectal-cancers-in-japan-WzbOC50pJr
SP - 1
EP - 8
VL - 14
IS - 1
DP - DeepDyve
ER -