TY - JOUR
AU1 - Samet, Jonathan D.
AU2 - Deng, Jie
AU3 - Schafernak, Kristian
AU4 - Arva, Nicoleta C.
AU5 - Lin, Xiaoqi
AU6 - Peevey, Joseph
AU7 - Fayad, Laura M.
AB - BackgroundPediatric bone marrow assessment by MRI is challenging and primarily experiential and qualitative, with a paucity of clinically useful quantitative imaging techniques.ObjectiveMRI fat fraction (MRI-FF) is a technique used to quantify the degree of fat in other organ systems. The purpose of this study was to assess whether MRI-FF accurately measures bone marrow composition.Materials and methodsThis two-part study included a validation phase, followed by an application phase. For the validation phase, the MRI-FF of piglet bones (6 long bones, 8 axial bones) was performed at 1.5 tesla (T) and 3.0 T, and correlated to the histological fat fraction (H-FF). We used Bland–Altman plots to compare MRI-FF at 1.5 tesla T and 3.0 T. For the application phase, five children with malignant marrow disease were recruited along with seven age- and gender-matched control subjects. The MRI-FF in the children was correlated to the H-FF. Boxplots were used to compare the MRI-FF of patients and control subjects.ResultsFor the validation animal study, the MRI-FF of piglet bones at both 1.5 T and 3.0 T demonstrated moderate positive correlation to H-FF (r=0.41 and 0.42, respectively). MRI-FF at 1.5 T and 3.0 T were in good agreement, on average 7.7% apart. For the application phase, we included 5 children (4 with leukemia, 1 rhabdomyosarcoma) with median age 7 years, range (3–10 years). All children had MRI-FF and H-FF below 10%. The MRI-FF in patients (3.8±1.2) was significantly lower than that of control subjects (46.1±12.3%) (P<0.01).ConclusionMRI-FF is a valid technique to assess bone marrow fat fraction at both 1.5 T and 3.0 T. The MRI-FF in children with malignant marrow processes is significantly lower than in control subjects with normal marrow.
TI - Quantitative magnetic resonance imaging for determining bone marrow fat fraction at 1.5T and 3.0T: a technique to noninvasively assess cellularity and potential malignancy of the bone marrow
JF - Pediatric Radiology
DO - 10.1007/s00247-020-04809-8
DA - 2020-09-05
UR - https://www.deepdyve.com/lp/springer-journals/quantitative-magnetic-resonance-imaging-for-determining-bone-marrow-X4FkEK3dc5
SP - 94
EP - 102
VL - 51
IS - 1
DP - DeepDyve
ER -