TY - JOUR
AU - Thornton, Janet M.
AB - A β‐bulge is a region of irregularity in a β‐sheet involving two β‐strands. It usually involves two or more residues in the bulged strand opposite to a single residue on the adjacent strand. These irregularities in β‐sheets were identified and classified automatically, extending the definition of β‐bulges given by Richardson et al. (Richardson, J.S., Getzoff, E.D., & Richardson, D.C., 1978, Proc. Natl. Acad. Sci. USA 75, 2574–2578). A set of 182 protein chains (170 proteins) was used, and a total of 362 bulges were extracted. Five types of β‐bulges were found: classic, G1, wide, bent, and special. Their characteristic amino acid preferences were found for most classes of bulges. Basically, bulges occur frequently in proteins; on average there are more than two bulges per protein. In general, β‐bulges produce two main changes in the structure of a β‐sheet: (1) disrupt the normal alternation of side‐chain direction; (2) accentuate the twist of the sheet, altering the direction of the surrounding strands.
TI - Identification, classification, and analysis of beta‐bulges in proteins
JF - Protein Science
DO - 10.1002/pro.5560021004
DA - 1993-10-01
UR - https://www.deepdyve.com/lp/wiley/identification-classification-and-analysis-of-beta-bulges-in-proteins-XW00668hkc
SP - 1574
EP - 1590
VL - 2
IS - 10
DP - DeepDyve
ER -