TY - JOUR
AU - Chen, Lieping
AB - B7-H1, a recently described member of the B7 family of costimulatory molecules, is thought to be involved in the regulation of cellular and humoral immune responses through the PD-1 receptor on activated T and B cells. We report here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1. In contrast, B7-H1 is abundant in human carcinomas of lung, ovary and colon and in melanomas. The pro-inflammatory cytokine interferon-γ upregulates B7-H1 on the surface of tumor cell lines. Cancer cell–associated B7-H1 increases apoptosis of antigen-specific human T-cell clones in vitro, and the apoptotic effect of B7-H1 is mediated largely by one or more receptors other than PD-1. In addition, expression of B7-H1 on mouse P815 tumor increases apoptosis of activated tumor-reactive T cells and promotes the growth of highly immunogenic B7-1+ tumors in vivo. These findings have implications for the design of T cell–based cancer immunotherapy.
TI - Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
JF - Nature Medicine
DO - 10.1038/nm730
DA - 2002-06-24
UR - https://www.deepdyve.com/lp/springer-journals/tumor-associated-b7-h1-promotes-t-cell-apoptosis-a-potential-mechanism-XcX7Unwpc7
SP - 793
EP - 800
VL - 8
IS - 8
DP - DeepDyve
ER -