TY - JOUR
AU1 - Truong, Van Gia
AU2 - Kim, Hyejin
AU3 - Lee, Byeong-Il
AU4 - Cha, Boram
AU5 - Jeong, Seok
AU6 - Oh, Sun-Ju
AU7 - Kang, Hyun Wook
AB - The current study aims to demonstrate the feasibility of a novel balloon-integrated optical catheter (BIOC) to achieve endoscopic laser application for circumferential coagulation of a tubular tissue structure. Both optical and thermal numerical simulations were developed to predict the propagation of laser light and a spatio-temporal distribution of temperature in tissue. Ex vivo esophagus tissue was tested with 980 nm laser light at 30 W for 90 s for quantitative evaluations. In vivo porcine models were used to validate the performance of BIOC for circumferential and endoscopic laser coagulation of esophagus in terms of acute tissue responses post-irradiation. Optical simulations confirmed that a diffusing applicator was able to generate a circumferential light distribution in a tubular tissue structure. Both numerical and experimental results presented that the maximum temperature elevation occurred at 3–5 mm (muscle layer) below the mucosa surface after 90 s irradiation. In vivo tests confirmed the circumferential delivery of laser light to a deep muscle layer as well as no evidence of thermal damage to the esophageal mucosa. The proposed BIOC can be a feasible optical device to provide circumferential laser irradiation as well as endoscopic coagulation of tubular esophagus tissue for clinical applications.
TI - Development of Novel Balloon-Integrated Optical Catheter for Endoscopic and Circumferential Laser Application
JF - Annals of Biomedical Engineering
DO - 10.1007/s10439-023-03228-8
DA - 2023-09-01
UR - https://www.deepdyve.com/lp/springer-journals/development-of-novel-balloon-integrated-optical-catheter-for-XgmxKqh2hK
SP - 2021
EP - 2034
VL - 51
IS - 9
DP - DeepDyve
ER -