TY - JOUR
AU - Su, Zhengchang
AB - Background: Cyclic AMP receptor protein (CRP), also known as catabolite gene activator protein (CAP), is an important transcriptional regulator widely distributed in many bacteria. The biological processes under the regulation of CRP are highly diverse among different groups of bacterial species. Elucidation of CRP regulons in cyanobacteria will further our understanding of the physiology and ecology of this important group of microorganisms. Previously, CRP has been experimentally studied in only two cyanobacterial strains: Synechocystis sp. PCC 6803 and Anabaena sp. PCC 7120; therefore, a systematic genome-scale study of the potential CRP target genes and binding sites in cyanobacterial genomes is urgently needed. Results: We have predicted and analyzed the CRP binding sites and regulons in 12 sequenced cyanobacterial genomes using a highly effective cis-regulatory binding site scanning algorithm. Our results show that cyanobacterial CRP binding sites are very similar to those in E. coli; however, the regulons are very different from that of E. coli. Furthermore, CRP regulons in different cyanobacterial species/ecotypes are also highly diversified, ranging from photosynthesis, carbon fixation and nitrogen assimilation, to chemotaxis and signal transduction. In addition, our prediction indicates that crp genes in modern cyanobacteria are likely inherited from a common ancestral gene in 
TI - Computational prediction of cAMP receptor protein (CRP) binding sites in cyanobacterial genomes
JF - BMC Genomics
DO - 10.1186/1471-2164-10-23
DA - 2009-01-15
UR - https://www.deepdyve.com/lp/springer-journals/computational-prediction-of-camp-receptor-protein-crp-binding-sites-in-Y7ac2BiWdy
SP - 1
EP - 16
VL - 10
IS - 1
DP - DeepDyve
ER -