TY - JOUR
AU - Banchereau, J
AB - Dendritic cells (DCs) are important in regulating both immunity and tolerance. Hence, we hypothesized that systemic lupus erythematosus (SLE), an autoimmune disease characterized by autoreactive B and T cells, may be caused by alterations in the functions of DCs. Consistent with this, monocytes from SLE patients' blood were found to function as antigen-presenting cells, in vitro. Furthermore, serum from SLE patients induced normal monocytes to differentiate into DCs. These DCs could capture antigens from dying cells and present them to CD4-positive T cells. The capacity of SLE patients' serum to induce DC differentiation correlated with disease activity and depended on the actions of interferon-alpha (IFN-alpha). Thus, unabated induction of DCs by IFN-alpha may drive the autoimmune response in SLE.
TI - Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.
JF - Science (New York, N.Y.)
DO - 10.1126/science.1064890
DA - 2002-02-05
UR - https://www.deepdyve.com/lp/pubmed/induction-of-dendritic-cell-differentiation-by-ifn-alpha-in-systemic-YNK8prXGNG
SP - 1540
EP - 3
VL - 294
IS - 5546
DP - DeepDyve
ER -