TY - JOUR
AU - Glimcher, Laurie H
AB - T-bet is a member of the T-box family of transcription factors that appears to regulate lineage commitment in CD4 T helper (TH) lymphocytes in part by activating the hallmark TH1 cytokine, interferon-gamma (IFN-gamma). IFN-gamma is also produced by natural killer (NK) cells and most prominently by CD8 cytotoxic T cells, and is vital for the control of microbial pathogens. Although T-bet is expressed in all these cell types, it is required for control of IFN-gamma production in CD4 and NK cells, but not in CD8 cells. This difference is also apparent in the function of these cell subsets. Thus, the regulation of a single cytokine, IFN-gamma, is controlled by distinct transcriptional mechanisms within the T cell lineage.
TI - Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
JF - Science (New York, N.Y.)
DO - 10.1126/science.1065543
DA - 2002-02-04
UR - https://www.deepdyve.com/lp/pubmed/distinct-effects-of-t-bet-in-th1-lineage-commitment-and-ifn-gamma-Ykg3ByG7Tp
SP - 338
EP - 342
VL - 295
IS - 5553
DP - DeepDyve
ER -