TY - JOUR
AU - 
AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY VOL. 283, NO. 32, pp. 21934 –21944, August 8, 2008 © 2008 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in the U.S.A. Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3 Received for publication, March 31, 2008, and in revised form, May 14, 2008 Published, JBC Papers in Press, June 11, 2008, DOI 10.1074/jbc.M802481200 Ele´onore Beurel and Richard S. Jope From the Department of Psychiatry and Behavioral Neurobiology, University of Alabama, Birmingham, Alabama 35294-0017 Excessive neuroinflammation contributes to many neurolog- A central component of inflammatory signaling is the Janus ical disorders and is poorly controlled therapeutically. The sig- kinase (JAK) /signal transducer and activator of transcription nal transducer and activator of transcription (STAT) family of (STAT) cascade (4). Activated by cytokines and interferons, transcription factors has a central role in inflammatory reac- receptor-associated tyrosine kinase JAKs phosphorylate tions, being stimulated by multiple cytokines and interferons STATs on an activating tyrosine residue (e.g. Tyr -STAT1 and regulating the expression of many proteins involved in and Tyr -STAT3). STATs are nucleocytoplasmic shuttling inflammation. We found that STAT3 activation is highly transcription factors that accumulate in the nucleus as a result dependent 
TI - Differential Regulation of STAT Family Members by Glycogen Synthase Kinase-3
JF - Journal of Biological Chemistry
DO - 10.1074/jbc.m802481200
DA - 2008-08-01
UR - https://www.deepdyve.com/lp/unpaywall/differential-regulation-of-stat-family-members-by-glycogen-synthase-Z49ALGdEO2
DP - DeepDyve
ER -