TY - JOUR
AU - Keegan, Achsah D
AB - Cytokines are inflammatory mediators important in responding to pathogens and other foreign challenges. Interleukin-4 (IL-4) and IL-13 are two cytokines produced by T helper type 2 cells, mast cells, and basophils. In addition to their physiological roles, these cytokines are also implicated in pathological conditions such as asthma and allergy. IL-4 can stimulate two receptors, type I and type II, whereas IL-13 signaling is mediated only by the type II receptor (see the STKE Connections Maps). These cytokines activate the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling cascades, which may contribute to allergic responses. In addition, stimulation of the phosphatidylinositol 3-kinase (PI3K) pathway through recruitment of members of the insulin receptor substrate family may contribute to survival and proliferation.
TI - Interleukin-4 and interleukin-13 signaling connections maps.
JF - Science (New York, N.Y.)
DO - 10.1126/science.1085458
DA - 2003-06-26
UR - https://www.deepdyve.com/lp/pubmed/interleukin-4-and-interleukin-13-signaling-connections-maps-Z6OEEaAuY1
SP - 1527
EP - 8
VL - 300
IS - 5625
DP - DeepDyve
ER -