TY - JOUR
AU - Giovannucci, Edward L.
AB - To evaluate the associations between coffee and caffeine consumption and various health outcomes, we performed an umbrella review of the evidence from meta-analyses of observational studies and randomized controlled trials (RCTs). Of the 59 unique outcomes examined in the selected 112 meta-analyses of observational studies, coffee was associated with a probable decreased risk of breast, colorectal, colon, endometrial, and prostate cancers; cardiovascular disease and mortality; Parkinson's disease; and type-2 diabetes. Of the 14 unique outcomes examined in the 20 selected meta-analyses of observational studies, caffeine was associated with a probable decreased risk of Parkinson's disease and type-2 diabetes and an increased risk of pregnancy loss. Of the 12 unique acute outcomes examined in the selected 9 meta-analyses of RCTs, coffee was associated with a rise in serum lipids, but this result was affected by significant heterogeneity, and caffeine was associated with a rise in blood pressure. Given the spectrum of conditions studied and the robustness of many of the results, these findings indicate that coffee can be part of a healthful diet.
TI - Coffee, Caffeine, and Health Outcomes: An Umbrella Review
JF - Annual Review of Nutrition
DO - 10.1146/annurev-nutr-071816-064941
DA - 2017-08-21
UR - https://www.deepdyve.com/lp/annual-reviews/coffee-caffeine-and-health-outcomes-an-umbrella-review-ZL1Z8DMTi7
SP - 131
EP - 156
VL - 37
IS - 
DP - DeepDyve
ER -