TY - JOUR
AU - Waldmann, Herman
AB -  'oepattments of pathology and 'Haematology, University of Cambridge Received for publication 4 January, accepted 10 January 1990 The CAMPATH-1 antigen is unusual among lymphocyte surface antigens in several respects. It is an abundant molecule, widely distributed on most, if not all, human lymphocytes. All of the antibodies obtained against it probably recognise a carbohydrate epitope and they are unusually lytic with complement. This property was responsible for their discovery since we were searching for antibodies which could be used to deplete T cells from bone marrow in order to prevent graft-versushost disease. From a single fusion of the Y3 rat myeloma line with a spleen from a rat immunised with human T lymphocytes, at least 7 distinct clones were isolated which produced antibodies that could lyse T cells in the presence of human complement (1,2). These antibodies had the same tissue distribution and could mutually inhibit the binding of each other. It was later shown by Western blotting that they all recognise the same antigen. Subsequently, other antibodies with the same properties were isolated both in our laboratory (3) and in that of Alain Bernard (4)(Table 1). The prototype, CAMPATH-1M (rat IgM), was submitted to the third leucocyte 
TI - The CAMPATH‐1 antigen (CDw52)
JO - Tissue Antigens
DO - 10.1111/j.1399-0039.1990.tb01767.x
DA - 1990-03-01
UR - https://www.deepdyve.com/lp/wiley/the-campath-1-antigen-cdw52-ZX4fKo3iLk
SP - 118
VL - 35
IS - 3
DP - DeepDyve
ER -