TY - JOUR
AU - Sher, Alan
AB - The activation of dendritic cells (DC) to produce interleukin 12 (IL-12) is thought to be a key step in the initiation of cell-mediated immunity to intracellular pathogens. Here we show that ligation of the C–C chemokine receptor (CCR) 5 can provide a major signal for the induction of IL-12 synthesis by the CD8α+ subset of DC and that this pathway is important in establishing interferon γ-dependent resistance to the protozoan parasite Toxoplasma gondii. These findings support the concept that the early induction of chemokines by invading pathogens is a critical step not only for the recruitment of DC but also for the determination of their subsequent immunologic function.
TI - CCR5 provides a signal for microbial induced production of IL-12 by CD8α+ dendritic cells
JF - Nature Immunology
DO - 10.1038/76957
DA - 2000-07-01
UR - https://www.deepdyve.com/lp/springer-journals/ccr5-provides-a-signal-for-microbial-induced-production-of-il-12-by-ZZ4wZSfHIB
SP - 83
EP - 87
VL - 1
IS - 1
DP - DeepDyve
ER -