TY - JOUR
AU - Goodman, Myron F
AB - c o r r e s P o n D e n c e Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA 7,8 To the Editor: A3G molecules . A processivity factor that is (W = A/T, R = purine) hot spot deamination 1 9 The article by Nowarski and colleagues , substantially larger than 1 indicates that most motif for the APOBEC family enzyme AID . “Hypermutation by intersegmental transfer double deaminations are caused by a single Returning to the issue of intersegmental of APOBEC3G cytidine deaminase” claims A3G molecule acting at both CCC motifs. The transfer, the authors have proposed that their first that apolipoprotein B mRNA– editing A3G processivity factor on ssDNA is about 7 on data do not support the sliding and jumping 7,8 7 enzyme, catalytic polypeptide–like (APOBEC) average ; thus, most double deaminations model suggested by us earlier because they 3G (A3G) deaminates deoxycytidines by are caused by a single A3G molecule. In do not observe consecutive deaminations a mechanism predominantly involving these experiments, typically less than 10% occurring in adjacent CCC motifs . Contrary intersegmental transfer. A protein moving of the ssDNA substrates are deaminated, to the author’s interpretation, we 
TI - Mechanisms of APOBEC3G-catalyzed processive deamination of deoxycytidine on single-stranded DNA
JF - Nature Structural & Molecular Biology
DO - 10.1038/nsmb0509-454
DA - 2009-05-01
UR - https://www.deepdyve.com/lp/springer-journals/mechanisms-of-apobec3g-catalyzed-processive-deamination-of-aSXVSA9iLj
SP - 454
EP - 455
VL - 16
IS - 5
DP - DeepDyve
ER -