TY - JOUR AU1 - Marshall, Fiona H. AB - [GABAB receptors are the metabotrophic receptors for GABA. They are members of the G-protein coupled superfamily of receptors but are highly unusual as they are made up of a dimer of 7-transmembrane spanning subunits. The receptors are widely distributed throughout the central nervous system where they act post-synaptically to cause a long-lasting hyperpolarisation through the activation of a potassium conductance. They are also present pre-synaptically where they act as auto and heteroreceptors to inhibit neurotransmitter release. GABAB receptors play a complex role in the regulation of excitatory transmission and their activation can have both inhibitory and dis-inhibitory effects. This has profound physiological and behavioural consequences including modification of LTP and memory, regulation of seizure activity and nociception. ] TI - Inhibitory Regulation of Excitatory Neurotransmission: The Role of GABAB Receptors in the Regulation of Excitatory Neurotransmission DA - 2007-06-05 UR - https://www.deepdyve.com/lp/springer-journals/inhibitory-regulation-of-excitatory-neurotransmission-the-role-of-acd4rbPKy1 DP - DeepDyve ER -