TY - JOUR
AU - Eckstein, Felix
AB - IntroductionKnee osteoarthritis (OA) represents the most common form of arthritis and causes chronic disability and pain, particularly in the elderly . Obesity is one of the most important modifiable risk factors for knee OA and has been a recent focus of attempts to reduce the impact of the disease . Since mechanical factors have failed to fully explain the relationship between obesity and increased OA risk , the mechanism of adiposity‐derived inflammation has garnered great recent interest in OA research. Proinflammatory mediators secreted by adipocytes, known as adipokines (e.g., leptin, interleukin‐6), have been shown to promote articular tissue degradation , and adipose tissue may play an important endocrine role in the pathophysiology of OA .Significance & InnovationsThe complex design using a within‐person and a between‐person analysis of 1:1 matched case and controls circumvents previous limitations given by interindividual confounders.Although the adipose tissue of the infrapatellar fat pad represents a source of intraarticular inflammation (cytokines), the morphology of the infrapatellar fat pad does not appear to be related to knee pain.Infrapatellar fat pad size does not differ between painful knees versus contralateral painless knees (within‐person study design) and between chronic painful knees versus 1:1 matched painless knees (between‐person study design).The 
TI - Relationship Between Knee Pain and Infrapatellar Fat Pad Morphology: A Within‐ and Between‐Person Analysis From the Osteoarthritis Initiative
JF - Arthritis Care & Research
DO - 10.1002/acr.23326
DA - 2018-01-01
UR - https://www.deepdyve.com/lp/wiley/relationship-between-knee-pain-and-infrapatellar-fat-pad-morphology-a-b4PGJ4POh1
SP - 550
EP - 557
VL - 70
IS - 4
DP - DeepDyve
ER -