TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on December 18, 2021 - Published by Cold Spring Harbor Laboratory Press RESEARCH COMMUNICATION promoter (AdMLP) (Li et al. 1994), the growth arrest gene Transactivation-defective gadd45 (Marhin et al. 1997), C/EBPa (Mink et al. 1996), c-MycS retains the ability and the growth arrest gene gas1 (Lee et al. 1997). The carboxyl terminus of c-Myc, containing the basic to regulate proliferation region (B) and helix–loop–helix/leucine zipper (HLH/LZ) and apoptosis domain, is necessary and sufficient for sequence-specific DNA binding and heterodimerization with Max (Fig. 1a). Qiurong Xiao, Gisela Claassen, Jingyu Shi, The amino terminus, containing two highly conserved 1 1 Susumu Adachi, John Sedivy, regions termed Myc box (Mb) I and II, is necessary for and Stephen R. Hann transcriptional activation and repression (Fig. 1a). Both the transactivation domain (TAD) and the BHLH/LZ do- Department of Cell Biology, Vanderbilt University School main have been shown to be necessary for biological ac- of Medicine, Nashville, Tennessee 37232-2175 USA; tivity (Henriksson and Lu ¨ scher 1996). Department of Molecular Biology, Cell Biology, Our previous studies found that human, murine, and and Biochemistry, Brown University, Providence, Rhode Island 02912 USA avian cells express different translational forms of c-Myc (Fig. 1a) that 
TI - Transactivation-defective c-MycS retains the ability to regulate proliferation and apoptosis
JF - Genes & Development
DO - 10.1101/gad.12.24.3803
DA - 1998-12-15
UR - https://www.deepdyve.com/lp/unpaywall/transactivation-defective-c-mycs-retains-the-ability-to-regulate-b8CG2XWUQV
DP - DeepDyve
ER -