TY - JOUR
AU - Jhoti, Harren
AB - This article describes the application of a high‐throughput X‐ray crystallographic fragment‐based screening methodology to identify low‐molecular‐weight leads for structure‐based optimisation into protein kinase inhibitors. The identification of two novel p38α MAP kinase inhibitors (with IC50=65 and 150 nM) starting from low‐molecular‐weight fragments is described.
TI - The Discovery of Novel Protein Kinase Inhibitors by Using Fragment‐Based High‐Throughput X‐ray Crystallography
JF - ChemBioChem
DO - 10.1002/cbic.200400188
DA - 2005-03-04
UR - https://www.deepdyve.com/lp/wiley/the-discovery-of-novel-protein-kinase-inhibitors-by-using-fragment-bgvq70kiB4
SP - 506
EP - 512
VL - 6
IS - 3
DP - DeepDyve
ER -