TY - JOUR AU - Jhoti, Harren AB - This article describes the application of a high‐throughput X‐ray crystallographic fragment‐based screening methodology to identify low‐molecular‐weight leads for structure‐based optimisation into protein kinase inhibitors. The identification of two novel p38α MAP kinase inhibitors (with IC50=65 and 150 nM) starting from low‐molecular‐weight fragments is described. TI - The Discovery of Novel Protein Kinase Inhibitors by Using Fragment‐Based High‐Throughput X‐ray Crystallography JF - ChemBioChem DO - 10.1002/cbic.200400188 DA - 2005-03-04 UR - https://www.deepdyve.com/lp/wiley/the-discovery-of-novel-protein-kinase-inhibitors-by-using-fragment-bgvq70kiB4 SP - 506 EP - 512 VL - 6 IS - 3 DP - DeepDyve ER -