TY - JOUR
AU1 - Overstreet, D. H.
AU2 - Pucilowski,  Olgierd
AU3 - Djuric,  Veljko
AB - Psychopharmacology (1997) 134:359–360 © Springer-Verlag 1997 COMMENTAR Y &roles:David H. Overstreet · Olgierd Pucilowski Veljko Djuric The current review of the chronic mild stress (CMS) mod- contribute to depressive disorders in humans (Craddock el by Willner (1997) has focussed on the replicability of and McGuffin 1993; Berrettini 1995; McGuffin et al. the procedure as demonstrated by its success in six of the 1996). There is an active campaign at present to detect seven laboratories which have routinely used the model. those genes which are associated with depression in hu- However, there was a brief mention in the article about mans and there have been some relative successes with strain differences and the one dissenting laboratory ap- bipolar disorders (Berrettini 1995). The genetics of uni- peared to have used a more “severe” environmental proce- polar disorders is more complex because of phenocopies, dure. Therefore, the focus of this commentary will be on the production of individuals with similar symptomatolo- genetic/environmental interactions in the CMS procedure. gy purely from environmental factors. Thus, one might The Flinders Sensitive Line (FSL) rat was selectively suggest that the CMS-treated outbred rat is a phenocopy bred for increased cholinergic responses, a feature seen of the 
TI - Genetic/environment interactions in chronic mild stress
JF - Psychopharmacology
DO - 10.1007/s002130050468
DA - 1997-12-01
UR - https://www.deepdyve.com/lp/springer-journals/genetic-environment-interactions-in-chronic-mild-stress-byswiwJ6qS
SP - 359
EP - 360
VL - 134
IS - 4
DP - DeepDyve
ER -