TY - JOUR AU - Garneau‐Tsodikova, Sylvie AB - Let′s ChAT about AD: We have successfully developed a chemoenzymatic methodology that utilizes the human choline acetyltransferase (hChAT) for the production of potential acetyl/buturylcholinesterase inhibitors to target Alzheimer's disease (AD). We have kinetically characterized and demonstrated the promisucity of this enzyme for choline analogue substrates and coenzyme A cosubstrates. TI - hChAT: A Tool for the Chemoenzymatic Generation of Potential Acetyl/Butyrylcholinesterase Inhibitors JF - ChemBioChem DO - 10.1002/cbic.200900309 DA - 2009-09-04 UR - https://www.deepdyve.com/lp/wiley/hchat-a-tool-for-the-chemoenzymatic-generation-of-potential-acetyl-c8A1oaaond SP - 2191 EP - 2194 VL - 10 IS - 13 DP - DeepDyve ER -