TY - JOUR
AU - Garneau‐Tsodikova, Sylvie
AB - Let′s ChAT about AD: We have successfully developed a chemoenzymatic methodology that utilizes the human choline acetyltransferase (hChAT) for the production of potential acetyl/buturylcholinesterase inhibitors to target Alzheimer's disease (AD). We have kinetically characterized and demonstrated the promisucity of this enzyme for choline analogue substrates and coenzyme A cosubstrates.
TI - hChAT: A Tool for the Chemoenzymatic Generation of Potential Acetyl/Butyrylcholinesterase Inhibitors
JF - ChemBioChem
DO - 10.1002/cbic.200900309
DA - 2009-09-04
UR - https://www.deepdyve.com/lp/wiley/hchat-a-tool-for-the-chemoenzymatic-generation-of-potential-acetyl-c8A1oaaond
SP - 2191
EP - 2194
VL - 10
IS - 13
DP - DeepDyve
ER -