TY - JOUR
AU1 - Bird, Adrian
AB - Bird Epigenetics & Chromatin 2013, 6(Suppl 1):O6 http://www.epigeneticsandchromatin.com/content/6/S1/O6 ORAL PRESENTATION Open Access The dinucleotide CG as a genomic signalling module Adrian Bird From Epigenetics and Chromatin: Interactions and processes Boston, MA, USA. 11-13 March 2013 The DNA sequence 5’CG (CpG) is self-complementary and can exist in three major chemical forms depending on the modification status of its cytosine moiety. To under- stand the functional significance of the CpG dinucleotide, we study proteins that bind either its methylated or unmethylated form. These proteins are likely mediators of CpG signalling that influence chromatin modification and thereby genome activity. The local density of CpG varies dramatically within genomic DNA. In the bulk genome CpG is rare and highly methylated, but in so-called “CpG islands” (CGIs) it is dense and usually non-methylated. A signature histone mark at non-methylated CGIs and also at transcriptionally active genes is trimethylation of his- tone H3 lysine 4. We are exploring the mechanisms by which DNA sequence features that are shared by all CGIs influence this and other epigenetic marks. In contrast, pro- teins that interact with methyl-CpG are thought to pro- mote gene silencing by recruiting transcriptional corepressors. In particular mutations in the gene for the methyl-CpG 
TI - The dinucleotide CG as a genomic signalling module
JF - Epigenetics & Chromatin
DO - 10.1186/1756-8935-6-S1-O6
DA - 2013-03-18
UR - https://www.deepdyve.com/lp/springer-journals/the-dinucleotide-cg-as-a-genomic-signalling-module-cEUt3MNJIg
SP - 1
EP - 1
VL - 6
IS - 1
DP - DeepDyve
ER -