TY - JOUR
AU - a Eugenia
AB - CLINICAL INVESTIGATION Genetic Polymorphisms in Apolipoprotein E and Glutathione Peroxidase 1 Genes in the Ecuadorian Population Affected With Alzheimer’s Disease Ce ´sar Paz-y-Min ˜ o, MD, Caty Carrera, MD, Andre ´s Lo ´ pez-Corte ´s, BSC, María Jose´Mun ˜ oz, BSC, Nadia Cumbal, BSC, Bernardo Castro, BSC, Alejandro Cabrera, BSC and María Eugenia Sa ´ nchez, MSC The brains affected by the disorder are known for pre- Abstract: Introduction: The main objective of this study is to deter- senting neuritic plaques and neurofibrilar tangles placed diffu- mine the prevalence of apolipoprotein E (Apo E) and glutathione sively throughout the cerebral cortex and hippocampus. In peroxidase 1 (GPX1) polymorphisms and their influence on the devel- addition, the amyloid deposit can be found in arteries, venules opment of Alzheimer disease (AD) in the Ecuadorian population. or capillaries of the cerebral cortex. The neuropathologic and Methods: The authors performed an analytic transversal case-control biochemical changes found in the disease include the arising study. The study group (n 
 39) consisted of patients with AD and production of amyloid protein, a process that blocks synapses, dementia. The control group (n 
 39) comprised elderly adults who alters physiology and causes neuronal death. have 
TI - Genetic Polymorphisms in Apolipoprotein E and Glutathione Peroxidase 1 Genes in the Ecuadorian Population Affected With Alzheimer's Disease
JF - American Journal of the Medical Sciences
DO - 10.1097/MAJ.0b013e3181e93475
DA - 2010-11-01
UR - https://www.deepdyve.com/lp/wolters-kluwer-health/genetic-polymorphisms-in-apolipoprotein-e-and-glutathione-peroxidase-1-cujmW006PY
SP - 373
EP - 377
VL - 340
IS - 5
DP - DeepDyve
ER -