TY - JOUR
AU - Roberts, N. A.
AB - A combination of three anti-HIV compounds (AZT, ddC and saquinavir) has been studied in vitro. In confirmation and extension of previous studies, a greater than additive effect was found against both HIV-1GB8 and HIV-1N1T, when any two compounds were combined. Synergy of action was also found against both virus strains when all three compounds were employed together. Cytotoxicological studies indicated that a high therapeutic index could be maintained for this treatment. The potential benefits of improved anti-HIV surveillance, reduced risk of the development of resistance to the treatment and reduced requirement for drugs in quantities that produce toxic side-effects support the extension of clinical trials of saquinavir to investigate this combination.
TI - In vitro anti-HIV and Cytotoxicological Evaluation of the Triple Combination: AZT and ddC with HIV Proteinase Inhibitor Saquinavir (Ro 31-8959): 
JO - Antiviral Chemistry and Chemotherapy
DO - 10.1177/095632029400500605
DA - 2016-06-23
UR - https://www.deepdyve.com/lp/sage/in-vitro-anti-hiv-and-cytotoxicological-evaluation-of-the-triple-cz6fuzyqzU
SP - 380
EP - 386
VL - 5
IS - 6
DP - DeepDyve
ER -