TY - JOUR AU - AB - THE JOURNAL OF BIOLOGICAL CHEMISTRY Vol. 277, No. 18, Issue of May 3, pp. 15851–15858, 2002 © 2002 by The American Society for Biochemistry and Molecular Biology, Inc. Printed in U.S.A. A Zinc-finger Protein, PLAGL2, Induces the Expression of a Proapoptotic Protein Nip3, Leading to Cellular Apoptosis* Received for publication, November 30, 2001, and in revised form, February 4, 2002 Published, JBC Papers in Press, February 6, 2002, DOI 10.1074/jbc.M111431200 Atsushi Mizutani‡, Takako Furukawa§, Yasushi Adachi¶, Susumu Ikehara¶, and Shigeru Taketani‡ From the ‡Department of Biotechnology, Kyoto Institute of Technology, Sakyo-ku, Kyoto 606-8585, Japan, the §Biomedical Imaging Research Center, Fukui Medical University, Matsuoka-cho, Fukui 910-1193, Japan, and the ¶First Department of Pathology, Kansai Medical University, Moriguchi, Osaka 570-8506, Japan Pleomorphic adenomas gene-like 2 (PLAGL2) protein be the key to this survival, the factors that determine the fate H zinc finger motifs exhibits DNA of individual cells under hypoxia are poorly understood. containing seven C 2 2 binding and transcriptional activation activity and is Hypoxia-inducible factor-1 (HIF-1), a well known mediator expressed in response to hypoxia or iron deficiency. To of hypoxic response in mammalian cells, is a heterodimer com- identify the target genes of PLAGL2, we transfected posed of TI - A Zinc-finger Protein, PLAGL2, Induces the Expression of a Proapoptotic Protein Nip3, Leading to Cellular Apoptosis JF - Journal of Biological Chemistry DO - 10.1074/jbc.m111431200 DA - 2002-05-01 UR - https://www.deepdyve.com/lp/unpaywall/a-zinc-finger-protein-plagl2-induces-the-expression-of-a-proapoptotic-d2YKBQfDg6 DP - DeepDyve ER -