TY - JOUR
AU - Lange, Christoph
AB - The Human Genome Project and its spin-offs are making it increasingly feasible to determine the genetic basis of complex traits using genome-wide association studies. The statistical challenge of analyzing such studies stems from the severe multiple-comparison problem resulting from the analysis of thousands of SNPs. Our methodology for genome-wide family-based association studies, using single SNPs or haplotypes, can identify associations that achieve genome-wide significance. In relation to developing guidelines for our screening tools, we determined lower bounds for the estimated power to detect the gene underlying the disease-susceptibility locus, which hold regardless of the linkage disequilibrium structure present in the data. We also assessed the power of our approach in the presence of multiple disease-susceptibility loci. Our screening tools accommodate genomic control and use the concept of haplotype-tagging SNPs. Our methods use the entire sample and do not require separate screening and validation samples to establish genome-wide significance, as population-based designs do.
TI - Genomic screening and replication using the same data set in family-based association testing
JF - Nature Genetics
DO - 10.1038/ng1582
DA - 2005-06-05
UR - https://www.deepdyve.com/lp/springer-journals/genomic-screening-and-replication-using-the-same-data-set-in-family-dBA9QPTv05
SP - 683
EP - 691
VL - 37
IS - 7
DP - DeepDyve
ER -