TY - JOUR
AU - 
AB - Downloaded from genesdev.cshlp.org on October 22, 2021 - Published by Cold Spring Harbor Laboratory Press GCD10, a translational repressor of GCN. 4, is the RNA-binding subunit of eukaryouc translation initiation factor-3 Minerva T. Garcia-Barrio, ~,2,4 Tatjana Naranda, 3'4 Carlos R. Vazquez de Aldana, 2 Rafael Cuesta, ~ Alan G. Hinnebusch, 2 John W.B. Hershey, 3 and Mercedes Tamame l's lInstituto de Microbiologia-Bioquimica, Consejo Superior de Investigaciones Cientificas/Universidad de Salamanca, Facultad de Biologia, 37008 Salamanca, Spain; 2Section on Molecular Genetics of Lower Eukaryotes, Laboratory of Molecular Genetics, National Institute of Child Health and Human Development, Bethesda, Maryland 20892 USA; aDepartment of Biological Chemistry, School of Medicine, University of California, Davis, California 95616 USA GCN4 mRNA is translated by a reinitiation mechanism involving four short upstream open reading frames (uORFs) in its leader sequence. Decreasing the activity of eukaryotic initiation factor-2 (eIF-2) by phosphorylation inhibits general translation in yeast but stimulates GCN4 expression by allowing ribosomes to scan past the uORFs and reinitiate at GCN4 instead. GCDIO was first identified genetically as a translational repressor of GCN4. We show here that GCD10 is an essential protein of 54.6 kD that is required in vivo for the initiation of total protein synthesis. 
TI - GCD10, a translational repressor of GCN4, is the RNA-binding subunit of eukaryotic translation initiation factor-3.
JF - Genes & Development
DO - 10.1101/gad.9.14.1781
DA - 1995-07-15
UR - https://www.deepdyve.com/lp/unpaywall/gcd10-a-translational-repressor-of-gcn4-is-the-rna-binding-subunit-of-dreog0e00y
DP - DeepDyve
ER -