TY - JOUR
AU1 - Clay, Candice
AU2 - Donart, Nathan
AU3 - Fomukong, Ndingsa
AU4 - Knight, Jennifer
AU5 - Overheim, Katie
AU6 - Tipper, Jennifer
AU7 - Van Westrienen, Jesse
AU8 - Hahn, Fletcher
AU9 - Harrod, Kevin
AB - Background: Many respiratory viruses disproportionately impact the elderly. Likewise, advanced age correlated with more adverse disease outcomes following severe acute respiratory syndrome coronavirus (SARS-CoV) infection in humans. We used an aged African green monkey SARS-CoV infection model to better understand age-related mechanisms of increased susceptibility to viral respiratory infections. Nonhuman primates are critical translational models for such research given their similarities to humans in immune-ageing as well as lung structure. Results: Significant age- and infection-dependent differences were observed in both systemic and mucosal immune compartments. Peripheral lymphocytes, specifically CD8 T and B cells were significantly lower in aged monkeys pre- and post- SARS-CoV infection, while neutrophil and monocyte numbers were not impacted by age or infection status. Serum proinflammatory cytokines were similar in both age groups, whereas significantly lower levels of IL-1beta, IL-18, IL-6, IL-12 and IL-15 were detected in the lungs of SARS-CoV-infected aged monkeys at either 5 or 10 days post infection. Total lung leukocyte numbers and relative frequency of CD8 T cells, B cells, macrophages and dendritic cells were greatly reduced in the aged host during SARS-CoV infection, despite high levels of chemoattractants for many of these cells in the aged lung. Dendritic cells and monocytes/macrophages 
TI - Severe acute respiratory syndrome-coronavirus infection in aged nonhuman primates is associated with modulated pulmonary and systemic immune responses
JF - Immunity & Ageing
DO - 10.1186/1742-4933-11-4
DA - 2014-03-19
UR - https://www.deepdyve.com/lp/springer-journals/severe-acute-respiratory-syndrome-coronavirus-infection-in-aged-f1SKD9yIMI
SP - 1
EP - 16
VL - 11
IS - 1
DP - DeepDyve
ER -