TY - JOUR
AU - 
AB - REVIEW ARTICLE published: 19 May 2014 doi: 10.3389/fendo.2014.00076 The IGF hormonal network in endometrial cancer: functions, regulation, and targeting approaches 1 2 2 Ilan Bruchim , Rive Sarfstein and Haim Werner * Gynecologic Oncology Unit, Department of Obstetrics and Gynecology, Meir Medical Center, Kfar Sava, Israel Department of Human Molecular Genetics and Biochemistry, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Edited by: Epidemiological as well as clinical and experimental data identified the insulin-like growth Antonino Belfiore, University “Magna factors (IGF1, IGF2) as important players in gynecological cancers in general, and endome- Graecia” of Catanzaro, Italy trial tumors in particular. The IGF1 receptor (IGF1R), which mediates the proliferative and Reviewed by: anti-apoptotic activities of both ligands, emerged in recent years as a promising therapeu- Roberta Malaguarnera, University “Magna Graecia” of Catanzaro, Italy tic target in oncology. However, most clinical trials conducted so far led to mixed results, Adrian Vincent Lee, University of emphasizing the need to identify biomarkers that can predict responsiveness to anti-IGF1R- Pittsburgh, USA targeted therapies. This article will review recent data regarding the role and expression Giovanni Vitale, Istituto Auxologico of IGF system components in endometrial cancer. In addition, we will review data on 
TI - The IGF Hormonal Network in Endometrial Cancer: Functions, Regulation, and Targeting Approaches
JF - Frontiers in Endocrinology
DO - 10.3389/fendo.2014.00076
DA - 2014-05-19
UR - https://www.deepdyve.com/lp/unpaywall/the-igf-hormonal-network-in-endometrial-cancer-functions-regulation-fDguc2rpO5
DP - DeepDyve
ER -