TY - JOUR
AU1 - Dusenbery, Susan M.
AU2 - de Ferranti, Sarah D.
AU3 - Kerstein, Jason
AU4 - Mendelson, Michael
AU5 - Colan, Steven
AU6 - Gauvreau, Kimberlee
AU7 - Arya, Puneeta
AB - Our primary aim was to investigate the relationship between LVM and anthropometric measures including lean body mass (LBM) in obese pediatric subjects compared to normal weight controls. A retrospective chart review identified subjects 2–18 years old who were normotensive and had normal echocardiograms between 1995 and 2020 at Boston Children’s Hospital. LVM was calculated with the 5/6 area length rule from 2D echocardiograms. LBM was calculated with equations derived from dual-energy X-ray absorptiometry. Of the 2217 subjects who met inclusion criteria, 203 were obese and 2014 had normal weight. The median age was 11.9 (2.0–18.9); 46% were female. The median LVM was 94.5 g (59.3–134.3) in obese subjects vs. 78.0 g (51.5–107.7) in controls. The median LBM was 37.2 kg (18.9–50.6) in obese subjects vs. 30.5 kg (17.6–40.8) in controls. In control and obese subjects, LBM had the strongest correlation to LVM (R2 0.86, P < 0.001) and (R2 0.87, P < 0.001), respectively. There was at most a modest correlation between tissue Doppler velocity z-scores and LV mass, and the largest was Septal E′ z-score in obese subjects (r = − 0.31, P = 0.006). In this cohort, LBM was found to have the strongest relationship to LVM in obese subjects. The largest correlation between tissue Doppler velocity z-scores and LV mass was Septal E′ z-score. Future studies will evaluate which measurements are more closely aligned with clinical outcomes in obese children.
TI - Relationship of Left Ventricular Mass to Lean Body Mass in the Obese Pediatric Population
JF - Pediatric Cardiology
DO - 10.1007/s00246-023-03133-w
DA - 2024-03-01
UR - https://www.deepdyve.com/lp/springer-journals/relationship-of-left-ventricular-mass-to-lean-body-mass-in-the-obese-fVSzC2H21q
SP - 640
EP - 647
VL - 45
IS - 3
DP - DeepDyve
ER -