TY - JOUR
AU1 - Penno, Giuseppe
AU2 - Solini, Anna
AU3 - Bonora, Enzo
AU4 - Orsi, Emanuela
AU5 - Fondelli, Cecilia
AU6 - Zerbini, Gianpaolo
AU7 - Trevisan, Roberto
AU8 - Vedovato, Monica
AU9 - Cavalot, Franco
AU1 - Laviola, Luigi
AU1 - Nicolucci, Antonio
AU1 - Pugliese, Giuseppe
AB - Aims To define the contribution of chronic kidney disease (CKD) to excess mortality in patients with type 2 diabetes and identify the baseline variables associated with all-cause death in those with and without CKD using the RECursive Partition- ing and Amalgamation (RECPAM) method. Methods This observational, longitudinal, cohort study enrolled 15,773 consecutive non-dialytic patients with type 2 diabetes −1 in 19 Diabetes Clinics throughout Italy in 2006–2008. Based on the presence of albuminuria ≥ 30 mg day and/or estimated −1 −2 glomerular filtration rate (eGFR) < 60 mL min ·1.73 m at baseline, patients were classified as having or not CKD. Vital status was verified on October 31, 2015 for 99.26% of patients. Results Mortality increased with increasing albuminuria and eGFR category. Excess risk versus the general population was maximal in patients aged < 55 years in the worse albuminuria or eGFR category. Conversely, in subjects aged ≥ 75 years −1 −1 −2 with albuminuria < 10 mg day or eGFR ≥ 75  mL  min ·1.73 m , excess mortality was no longer detectable. At REC- −1 PAM analysis, the main correlates of death in the whole cohort were albuminuria > 44 mg day , prevalent CVD, and −1 −2 eGFR < ~ 75 mL min ·1.73 m ; gender, prevalent CVD, and higher 
TI - Defining the contribution of chronic kidney disease to all-cause mortality in patients with type 2 diabetes: the Renal Insufficiency And Cardiovascular Events (RIACE) Italian Multicenter Study
JF - Acta Diabetologica
DO - 10.1007/s00592-018-1133-z
DA - 2018-03-24
UR - https://www.deepdyve.com/lp/springer-journals/defining-the-contribution-of-chronic-kidney-disease-to-all-cause-gQ7fqfjekq
SP - 603
EP - 612
VL - 55
IS - 6
DP - DeepDyve
ER -