TY - JOUR
AU1 - Doherty, Jennifer
AU2 - Grieshober, Laurie
AU3 - Houck, John
AU4 - Barnett, Matt
AU5 - De Dieu Tapsoba, Jean
AU6 - Thornquist, Mark
AU7 - Wang, Ching-Yun
AU8 - Goodman, Gary
AU9 - Chen, Chu
AB - www.nature.com/bjc ARTICLE Epidemiolgy Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial 1,2 1 2 2 2 2 Jennifer Anne Doherty , Laurie Grieshober , John R. Houck , Matt J. Barnett , Jean De Dieu Tapsoba , Mark D. Thornquist , 2 2 2,3,4 Ching-Yun Wang , Gary E. Goodman and Chu Chen BACKGROUND: Telomeres protect cells from genomic instability. We examined telomere length and lung cancer risk prospectively in heavy smokers. METHODS: In a nested case–control study with 709 cases and 1313 controls, conditional logistic regression was used to evaluate associations between telomere length (global, chromosome 5p, and 13q) and lung cancer risk by histotype, controlling for detailed smoking history. RESULTS: Risks of overall lung cancer and adenocarcinoma were suggestively elevated among individuals with telomere length in the longest tertile. No clear patterns were observed for other histotypes, or for chromosome 5p or 13q telomere length. Associations with adenocarcinoma were strongest among (OR, 95% CI for longest versus shortest tertile): former smokers (2.26, 1.03–4.96), individuals <65 years (2.22, 1.13–4.35), and women (2.21, 0.99–4.93). CONCLUSIONS: Our large study of heavy smokers adds additional evidence that long telomere 
TI - Nested case–control study of telomere length and lung cancer risk among heavy smokers in the β-Carotene and Retinol Efficacy Trial
JF - British Journal of Cancer
DO - 10.1038/s41416-018-0075-0
DA - 2018-04-19
UR - https://www.deepdyve.com/lp/springer-journals/nested-case-control-study-of-telomere-length-and-lung-cancer-risk-gY00hN3SqL
SP - 1513
EP - 1517
VL - 118
IS - 11
DP - DeepDyve
ER -