TY - JOUR
AU - O'Garra, Anne
AB - TGF‐β plays an important role in immune regulation in vivo and affects T cell differentiation in vitro. Here we describe how TGF‐β modulates Th2 development in vitro and investigate its mechanisms of action. TGF‐β down‐regulated Th2 development of naive CD4+ Mel‐14high T cells derived from the DO11.10 ovalbumin‐specific TCR‐transgenic mouse, and this was observed both in cultures driven with anti‐CD3 and anti‐CD28 and with splenic APC and antigen. TGF‐β down‐regulated GATA‐3 expression in developing Th2 and these cells showed a diminished IL‐4‐induced STAT6 activation. We found, however, that naive cells driven in Th2 conditions with TGF‐β did not show a significantly decreased STAT6 activation, suggesting that TGF‐β inhibits Th2 development via a STAT6‐independent mechanism.
TI - TGF‐β1 down‐regulates Th2 development and results in decreased IL‐4‐induced STAT6 activation and GATA‐3 expression
JF - European Journal of Immunology
DO - 10.1002/1521-4141(200009)30:9<2639::AID-IMMU2639>3.0.CO;2-7
DA - 2000-09-01
UR - https://www.deepdyve.com/lp/wiley/tgf-1-down-regulates-th2-development-and-results-in-decreased-il-4-gvtKMlF0S1
SP - 2639
EP - 2649
VL - 30
IS - 9
DP - DeepDyve
ER -