TY - JOUR
AU1 - Asano, Toshifumi
AU2 - Kunikata, Hiroshi
AU3 - Yasuda, Masayuki
AU4 - Nishiguchi, Koji M.
AU5 - Abe, Toshiaki
AU6 - Nakazawa, Toru
AB - PurposeThis study searched for early predictive vascular biomarkers for visual outcomes in eyes with macular edema caused by branch retinal vein occlusion (BRVOME).MethodsTwenty-four eyes of 24 subjects with BRVOME were treated with the intravitreal injection of ranibizumab (IVR) for at least 6 months. We measured mean blur rate (MBR) in the optic nerve head (ONH) and vessel density (VD) in the macula with laser speckle flowgraphy and optical coherence tomography angiography, respectively.ResultsSix-month post-IVR best-corrected visual acuity (BCVA) was correlated positively with age, pre-IVR BCVA, 1-month post-IVR BCVA, 3-month post-IVR BCVA and pre-IVR systolic blood pressure (P < 0.001, P < 0.001, P < 0.001, P < 0.001 and P = 0.02, respectively) and negatively with pre-IVR overall MBR, 1-month post-IVR overall MBR, 6-month post-IVR overall MBR, 3-month post-IVR deep retinal capillary plexus (DCP) VD and 6-month post-IVR DCP VD (P = 0.03, P = 0.03, P = 0.02, P = 0.01 and P = 0.005, respectively). Furthermore, a multiple regression analysis showed that pre-IVR overall MBR (β =  − 0.67, P = 0.009) was among independent prognostic factors predicting 6-month post-IVR BCVA. Six-month post-IVR DCP VD was also correlated with overall MBR at all time points.ConclusionONH blood flow may be a pre-IVR biomarker of both visual outcomes and post-IVR deep macular microcirculation in eyes with BRVOME.
TI - Ocular microcirculation changes, measured with laser speckle flowgraphy and optical coherence tomography angiography, in branch retinal vein occlusion with macular edema treated by ranibizumab
JF - International Ophthalmology
DO - 10.1007/s10792-020-01562-7
DA - 2020-09-07
UR - https://www.deepdyve.com/lp/springer-journals/ocular-microcirculation-changes-measured-with-laser-speckle-flowgraphy-h1bSXUCY8o
SP - 151
EP - 162
VL - 41
IS - 1
DP - DeepDyve
ER -