TY - JOUR
AU1 - Sharma, Brij
AU2 - Katiyar, Harshita
AU3 - Barall, Deepesh
AU4 - Sharma, Neetu
AU5 - Agnihotry, Shikha
AU6 - Goel, Amit
AU7 - Aggarwal, Rakesh
AB - Hepatitis B virus (HBV) has several genotypes. In the Indian population, genotypes A and D are the most frequent. HBV infection is hyper-endemic in the Lahaul and Spiti district in Himachal Pradesh; however, the virus genotype in this area is not known. We sequenced a 398-nucleotide segment of HBV genome that included parts of pre-S1/S2 and polymerase genes from 17 specimens from this district, and assigned a viral genotype to these. Of the 17 specimens studied, 13 (76% [95% confidence interval = 50–92%]) showed the presence of genotype C HBV; the remaining four were genotype D (n = 4; 24%) HBV. Prevalence of genotype C HBV was much higher in the district than in other parts of India. This may reflect the historical mixing of this population with that in China. Since genotype C has a higher risk of chronicity and mother-to-child transmission, prevention of HBV infection may need particular emphasis in this area.
TI - Genotyping of hepatitis B virus isolates from Lahaul and Spiti district in Himachal Pradesh, India
JF - Indian Journal of Gastroenterology
DO - 10.1007/s12664-018-0854-9
DA - 2018-06-01
UR - https://www.deepdyve.com/lp/springer-journals/genotyping-of-hepatitis-b-virus-isolates-from-lahaul-and-spiti-hwiXdhcH3i
SP - 261
EP - 265
VL - 37
IS - 3
DP - DeepDyve
ER -