TY - JOUR
AU1 - Ablashi, D.V.
AU2 - Oie, H.K.
AU3 - Armstrong, G.R.
AU4 - Didier-Fichet, M.L.
AU5 - Tronick, S.R.
AU6 - Heine, U.
AU7 - Dalton, A.J.
AB - Murine Rauscher leukemia virus (MuRLV) from BALB/c plasma consistingof a mixture of an ecotropic and a xenotropic virus could be separated out by a selectionprocess when propagated in human and simian cell cultures. This hypothesis is supportedby obtaining consistently lower infectivity titers of human cell propagated RLV in humanand simian cells as compared to MuRLV propagated in mouse cell cultures. Furthermore,RLV passaged in a simian cell culture failed to replicate in mouse cells, had a wide hostrange, was able to rescue Moloney sarcoma genome, possessed murine type C groupspecificantigen, and was neutralized by anti-HRLV. Its reverse transcriptase was stronglyinhibited by antiserum to MuRLV enzyme; however, antiserum to woolly monkey enzymealso inhibited (30%) its reverse transcriptase, suggesting some difference in antigenicproperties. Inoculation of this virus in rhesus monkeys was inconclusive.
TI - Xenotropic Properties of an Isolate from Murine Rauscher Leukemia Virus in Primate
JF - Journal of Medical Primatology
DO - 10.1159/000459953
DA - 2017-01-01
UR - https://www.deepdyve.com/lp/karger/xenotropic-properties-of-an-isolate-from-murine-rauscher-leukemia-i3PlAIen0q
SP - 223
EP - 236
VL - 5
IS - 4
DP - DeepDyve
ER -