TY - JOUR
AU1 - Heikkilä, Katriina
AU2 - Madsen, Ida E. H.
AU3 - Nyberg, Solja T.
AU4 - Fransson, Eleonor I.
AU5 - Ahola, Kirsi
AU6 - Alfredsson, Lars
AU7 - Bjorner, Jakob B.
AU8 - Borritz, Marianne
AU9 - Burr, Hermann
AU1 - Dragano, Nico
AU1 - Ferrie, Jane E.
AU1 - Knutsson, Anders
AU1 - Koskenvuo, Markku
AU1 - Koskinen, Aki
AU1 - Nielsen, Martin L.
AU1 - Nordin, Maria
AU1 - Pejtersen, Jan H.
AU1 - Pentti, Jaana
AU1 - Rugulies, Reiner
AU2 - Oksanen, Tuula
AU2 - Shipley, Martin J.
AU2 - Suominen, Sakari B.
AU2 - Theorell, Töres
AU2 - Väänänen, Ari
AU2 - Vahtera, Jussi
AU2 - Virtanen, Marianna
AU2 - Westerlund, Hugo
AU2 - Westerholm, Peter J. M.
AU2 - Batty, G. David
AU3 - Singh-Manoux, Archana
AU3 - Kivimäki, Mika
AU3 - for the IPD-Work Consortium
AU3 - 
AB - Background and Aims: Many clinicians, patients and patient advocacy groups believe stress to have a causal role in inflammatory bowel diseases, such as Crohn’s disease and ulcerative colitis. However, this is not corroborated by clear epidemiological research evidence. We investigated the association between work-related stress and incident Crohn’s disease and ulcerative colitis using individual-level data from 95 000 European adults. Methods: We conducted individual-participant data meta-analyses in a set of pooled data from 11 prospective European studies. All studies are a part of the IPD-Work Consortium. Work-related psychosocial stress was operationalised as job strain (a combination of high demands and low control at work) and was self-reported at baseline. Crohn’s disease and ulcerative colitis were ascertained from national hospitalisation and drug reimbursement registers. The associations between job strain and inflammatory bowel disease outcomes were modelled using Cox proportional hazards regression. The study- specific results were combined in random effects meta-analyses. Results: Of the 95 379 participants who were free of inflammatory bowel disease at baseline, 111 men and women developed Crohn’s disease and 414 developed ulcerative colitis during follow-up. Job strain at baseline was not associated with incident Crohn’s disease (multivariable-adjusted random effects hazard ratio: 0.83, 95% confidence interval: 
TI - Job Strain and the Risk of Inflammatory Bowel Diseases: Individual-Participant Meta-Analysis of 95 000 Men and Women
JF - PLoS ONE
DO - 10.1371/journal.pone.0088711
DA - 2014-02-18
UR - https://www.deepdyve.com/lp/unpaywall/job-strain-and-the-risk-of-inflammatory-bowel-diseases-individual-ixIpM2N30d
DP - DeepDyve
ER -