TY - JOUR AU1 - Foucard, Tony AU2 - Strandberg, Kjell AB - Derivatives of phloretin (25–1,000 μg/ml) among them polyphloretin phosphate (PPP), inhibited in a dose-dependent manner anaphylactic (birch pollen or horse dander) histamine release from human lung tissue passively sensitized with reaginic serum. Pretreatment with PPP of lung tissue sensitized both to birch pollen and horse dander counteracted to a similar extent the release of histamine induced by either allergen administered in sequence. The phloretin derivatives also antagonized the constrictor action of prostaglandin F2α on isolated human bronchi at concentrations which did not impair the responses to histamine. The low and high molecular weight derivatives of phloretin were comparably active on a weight basis in both experimental systems. TI - Inhibition by Derivatives of Phloretin of Anaphylactic Histamine Release from Human Lung Tissue and of Prostaglandin F2α-Induced Bronchoconstriction JF - International Archives of Allergy and Immunology DO - 10.1159/000231298 DA - 1975-01-01 UR - https://www.deepdyve.com/lp/karger/inhibition-by-derivatives-of-phloretin-of-anaphylactic-histamine-jnPCi9rIQ4 SP - 132 EP - 142 VL - 48 IS - 1 DP - DeepDyve ER -