TY - JOUR
AU - Cronin, Mark T.D.
AB - The current status of quantitative structure–activity relationships (QSARs) in predicting toxicity is assessed. Widespread use of these methods to predict toxicity from chemical structure is possible, both by industry to develop new compounds, and also by regulatory agencies. The current use of QSARs is restricted by the lack of suitable toxicity data available for modelling, the unsuitability of simplistic modelling approaches for the prediction of certain endpoints, and the poor definition and utilisation of the applicability domain of models. Suggestions to resolve these issues are made.
TI - The Current Status and Future Applicability of Quantitative Structure–activity Relationships (QSARs) in Predicting Toxicity
JF - Alternatives to Laboratory Animals
DO - 10.1177/026119290203002S12
DA - 2002-12-01
UR - https://www.deepdyve.com/lp/sage/the-current-status-and-future-applicability-of-quantitative-structure-l00plKMUzD
SP - 81
EP - 84
VL - 30
IS - 2_suppl
DP - DeepDyve
ER -