TY - JOUR AU1 - Szymańska, J. A. AU2 - Bruchajzer, E. AU3 - Sporny, S. AU4 - Piotrowski, J. K. AB - Bull. Environ. Contam. Toxicol. (1998) 61:22-30 © 1998 Springer-Verlag New York Inc. Changes in Selected Indicators of Liver Impairment after Repeated Administration of Mono- and Polybromobenzenes in Mice 1 1 2 1 J. A. Szymanska, E. Bruchajzer, S. Sporny, J. K. Piotrowski Department of Toxicological Chemistry, Medical University of Lódz, 90-151 Lódz, Muszynskiego 1, Poland Department of Pathomorphology, Medical University of Lódz, 90-151 Lódz, Muszynskiego 1, Poland Received: 12 September 1997/Accepted: 30April 1998 Brominated benzene derivatives have been used as flame retardants during the past 20 years, and have become a potential source of environmental contamination. Hexabromobenzene and its metabolites are present in water, fish, birds, sediments and human tissues (Kashimoto and Tatsukawa 1986; Yamaguchi et al. 1988a; Watanabe and Tatsukawa 1989). Hexabromobenzene has been the most widely used of the polybromobenzenes. The products of hexabromobenzene debromination (penta-, tetra-, tribromobenzenes) are formed by means of environmental degradation or metabolism. They are more volatile and water soluble than the parent compound (Watanabe and Tatsukawa 1989). Dibromobenzenes found in natural environments may appear as a result of using them as fumigants, additives to cleaning agents, or as half-products in production of pharmaceutical preparations (Colacci et al. 1990). They may also arise TI - Changes in Selected Indicators of Liver Impairment after Repeated Administration of Mono- and Polybromobenzenes in Mice JF - Bulletin of Environmental Contamination and Toxicology DO - 10.1007/s001289900724 DA - 1998-07-01 UR - https://www.deepdyve.com/lp/springer-journals/changes-in-selected-indicators-of-liver-impairment-after-repeated-lbKGdGRlDb SP - 22 EP - 30 VL - 61 IS - 1 DP - DeepDyve ER -