TY - JOUR
AU - Ahmed, Rafi
AB - Interleukin (IL)-2 is currently used to enhance T-cell immunity but can have both positive and negative effects on T cells. To determine whether these opposing results are due to IL-2 acting differently on T cells depending on their stage of differentiation, we examined the effects of IL-2 therapy during the expansion, contraction and memory phases of the T-cell response in lymphocytic choriomeningitis virus (LCMV)–infected mice. IL-2 treatment during the expansion phase was detrimental to the survival of rapidly dividing effector T cells. In contrast, IL-2 therapy was highly beneficial during the death phase, resulting in increased proliferation and survival of virus-specific T cells. IL-2 treatment also increased proliferation of resting memory T cells in mice that controlled the infection. Virus-specific T cells in chronically infected mice also responded to IL-2 resulting in decreased viral burden. Thus, timing of IL-2 administration and differentiation status of the T cell are critical parameters in designing IL-2 therapies.
TI - Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo
JF - Nature Medicine
DO - 10.1038/nm866
DA - 2003-04-14
UR - https://www.deepdyve.com/lp/springer-journals/therapeutic-use-of-il-2-to-enhance-antiviral-t-cell-responses-in-vivo-mOUinxzo2c
SP - 540
EP - 547
VL - 9
IS - 5
DP - DeepDyve
ER -