TY - JOUR
AU1 - Patten, Scott B
AU2 - Burton, Jodie M
AU3 - Fiest, Kirsten M
AU4 - Wiebe, Samuel
AU5 - Bulloch, Andrew GM
AU6 - Koch, Marcus
AU7 - Dobson, Keith S
AU8 - Metz, Luanne M
AU9 - Maxwell, Colleen J
AU1 - Jetté, Nathalie
AB - Background:There is a role for brief assessment instruments in detection and management of major depression in MS. However, candidate scales have rarely been validated against a validated diagnostic interview. In this study, we evaluated the performance of several candidate scales: Patient Health Questionnaire (PHQ)-9, PHQ-2, Center for Epidemiologic Studies Depression rating scale (CES-D), and Hospital Anxiety and Depression Scale (HADS-D) in relation to the Structured Clinical Interview for DSM-IV (SCID).Methods:The sample was an unselected series of 152 patients attending a multiple sclerosis (MS) clinic. Participants completed the scales during a clinic visit or returned them by mail. The SCID was administered by telephone within two weeks. The diagnosis of major depressive episode, according to the SCID, was used as a reference standard. Receiver-operator curves (ROC) were fitted and indices of measurement accuracy were calculated.Results:All of the scales performed well, each having an area under the ROC > 90%. For example, the PHQ-9 had 95% sensitivity and 88.3% specificity when scored with a cut-point of 11. This cut-point achieved a 56% positive predictive value for major depression.Conclusions:While all of the scales performed well in terms of their sensitivity and specificity, the availability of the PHQ-9 in the public domain and its brevity may enhance the feasibility of its use.
TI - Validity of four screening scales for major depression in MS
JF - Multiple Sclerosis Journal
DO - 10.1177/1352458514559297
DA - 2015-07-01
UR - https://www.deepdyve.com/lp/sage/validity-of-four-screening-scales-for-major-depression-in-ms-mWglTmbZet
SP - 1064
EP - 1071
VL - 21
IS - 8
DP - DeepDyve
ER -