TY - JOUR
AU - Davis, R. J.
AB -  Mitogen-activated protein (MAP) kinases are proline-directed serine/threonine kinases that are activated by dual phosphorylation on threonine and tyrosine residues in response to a wide array of extracellular stimuli. Three distinct groups of MAP kinases have been identified in mammalian cells [extracellular-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38]. These MAP kinases are mediators of signal transduction from the cell surface to the nucleus. One nuclear target of these MAP kinase signaling pathways is the transcription factor AP-1. MAP kinases regulate AP-1 transcriptional activity by multiple mechanisms. Here we review recent progress towards understanding AP-1 regulation by the ERK, JNK, and p38 MAP kinase signal transduction pathways.
TI - Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
JF - Journal of Molecular Medicine
DO - 10.1007/s001090050063
DA - 1996-10-14
UR - https://www.deepdyve.com/lp/springer-journals/transcription-factor-ap-1-regulation-by-mitogen-activated-protein-nenA4OQX1M
SP - 589
EP - 607
VL - 74
IS - 10
DP - DeepDyve
ER -